Publicatii
2022
Comunicări la conferinţe
Radu BM, Amuzescu B, Mihailescu D, The ‘electric’ signature of a proarrhythmogenic drug, CNB 2022, 17th National Conference of Biophysics with International Participation, 23-29 septembrie 2022, Tg Mures, Romania, abstract publicat in Acta Marisiensis Seria Medica, volume 68, supplement 5, 2022 ISSN 2668-7755 (prezentare orala)
Radu BM, Amuzescu B, Assessing the safety profile of a drug – an itinerary from heart to brain, Romanian conference of Neuroscience and Physiology with international participation “From brain to heart and back”, 29 sep – 1 oct 2022, Bucharest, Romania, abstract publicat in Fiziologia (physiology), 2022 Supplement 1 (prezentare orala)
2023
Articole publicate in reviste indexate in baze de date internationale
Amuzescu B, Corlan A, Radu BM, Inhibitory effects of cenobamate on multiple human cardiac ion channels and possible arrhythmogenic consequences, preprint, DOI: 10.21203/rs.3.rs-3735338/v1, https://www.researchsquare.com/article/rs-3735338/v1
Comunicări la conferinţe
Radu BM, Stoica R, Rusu CM, Cojocaru F, Banciu A, Banciu DD, Amuzescu B, Drug safety assessment for cenobamate a recently FDA-approved antiepileptic, 11th IBRO World Congress of Neuroscience, 9-12 sep 2023, Granada Spain, abstract publicat in IBRO Neuroscience Reports 15 (2023) S67–S466 (poster)
Radu BM, A new FDA-approved antiepileptic drug, cenobamate, has pro-arrhythmogenic effects, 3rd International Conference on Neuroscience, Neuroinformatics, Neurotechnology and Neuro-Psycho-Pharmacology Bucharest, 26-28 oct 2023, Romanian Academy Library, Bucharest (prezentare orala)
Draghici I, Stoica R, Radu BM, Cenobamate upregulates P-glycoprotein, while downregulates tight junction proteins in accordance with blood-brain barrier permeabilization, 3rd International Conference on Neuroscience, Neuroinformatics, Neurotechnology and Neuro-Psycho-Pharmacology Bucharest, 26-28 oct 2023, Romanian Academy Library, Bucharest (poster)
Amuzescu B, Efectele cardiologice ale cenobamate – o cercetare proprie, Conferinta Nationala a XXXI, Conferinta SRIE (Societatea Romana Impotriva Epilepsiei), 23-24 noiembrie 2023, Hotel Novotel, Bucuresti (prezentare orala)
2024-2025
Articole publicate in reviste indexate ISI
Mateias AL, Armasescu F, Amuzescu B, Corlan AD, Radu BM, Inhibitory effects of cenobamate on multiple human cardiac ion channels and possible arrhythmogenic consequences, Biomolecules, 2024, 14(12), 1582; doi: 10.3390/biom14121582.
Sulea T, Draga S, Mernea M, Corlan AD, Radu BM, Petrescu AJ, Amuzescu B, Differential inhibition by cenobamate of canonical human Nav1.5 ion channels and several point mutants, International Journal of Molecular Sciences, 2025, 26(1):358, doi: 10.3390/ijms26010358.
Comunicări la conferinţe
Radu BM, Stoica R, Cojocaru F, Draghici I, Rusu CM, Banciu A, Banciu DD, Amuzescu B, Drug safety assessment for cenobamate by analyzing the action on blood brain barrier and the pro-arrhythmogenic effect, 18th National Conference of Biophysics with International Participation, CNB 2024, Iasi University of Life Sciences, 5-7 september 2024, Romania (prezentare orală)
Radu BM, Amuzescu B, Este cenobamatul un medicament sigur? Ziua Internaționala a Microorganismelor ZIM2024, ediția a IV-a, Platforma de Cercetare în Biologie și Ecologie Sistemică (PCBE), Facultatea de Biologie a Universității din București, 19 septembrie 2024 (prezentare orală)
Stoica R, Albisoru B, Amuzescu B, Radu BM, Investigating the impact of fenfluramine on P-glycoprotein expression and cardiac ionic channels, 18th National Conference of Biophysics with International Participation, CNB 2024, Iasi University of Life Sciences, 5-7 september 2024, Romania (poster)
Radu BM, Amuzescu B, Cenobamate – drug safety assessment for a new antiepileptic drug, SNN 2024, The annual National Neuroscience Society of Romania (SNN) conference with international participation, Nervous System-Body-Environment Connections in Health and Disease, 31 october – 2 november 2023, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy (prezentare orală)
Radu BM, Stoica R, Cojocaru F, Draghici I, Staicu CE, Rusu CM, Amuzescu B, Analiza siguranţei farmacologice a medicamentului antiepileptic cenobamat, Conferința Anuală de Comunicare a Rezultatelor Cercetării la Universitatea din București, 25-29 noiembrie 2024, Amfiteatrul „Ioan Mihăilescu”, Universitatea din București (prezentare orală)
Alte rezultate
Bianca Albişoru, Actiunea fenfluraminei asupra celulelor endoteliale din bariera hematoencefalica, iunie 2024, Lucrare de Licenţă, Universitatea din Bucureşti, Facultatea de Biologie, coordonator ştiinţific Prof Dr Beatrice Mihaela Radu
Ioana Pascale, Modificari functionale ale canalelor cardiace umane pentru Na+ voltaj-dependente induse de tratamentul cu cenobamat, iunie 2024, Lucrare de Licenţă, Universitatea din Bucureşti, Facultatea de Biologie, coordonator ştiinţific Prof Dr Beatrice Mihaela Radu, indrumător ştiinţific Conf Dr Bogdan Amuzescu
Andreea Larisa Mateiaş, Analiza sigurantei cardiace a medicamentului cenobamat prin tehnica de patch-clamp, martie – septembrie 2024, stagiu de cercetare, Master de Biotehnologie Medicala si Moleculara, Universitatea din Verona, Coordonatori ştiintifici Prof Paolo Francesco Fabene (Univr), Prof Beatrice Mihaela Radu şi Conf Bogdan Amuzescu (Unibuc)