Publications
2022
Communications at conferences
Radu BM, Amuzescu B, Mihailescu D, The ‘electric’ signature of a proarrhythmogenic drug, CNB 2022, 17th National Conference of Biophysics with International Participation, September 23-29, 2022, Tg Mures, Romania, abstract published in Acta Marisiensis Seria Medica, volume 68, supplement 5, 2022 ISSN 2668-7755 (oral presentation)
Radu BM, Amuzescu B, Assessing the safety profile of a drug – an itinerary from heart to brain, Romanian conference of Neuroscience and Physiology with international participation “From brain to heart and back”, 29 Sep – 1 Oct 2022, Bucharest, Romania, abstract published in Physiology, 2022 Supplement 1 (oral presentation)
2023
Articles published in journals indexed in international databases
Amuzescu B, Corlan A, Radu BM, Inhibitory effects of cenobamate on multiple human cardiac ion channels and possible arrhythmogenic consequences, preprint, DOI: 10.21203/rs.3.rs-3735338/v1, https://www.researchsquare.com/article/rs-3735338/v1
Communications at conferences
Radu BM, Stoica R, Rusu CM, Cojocaru F, Banciu A, Banciu DD, Amuzescu B, Drug safety assessment for cenobamate a recently FDA-approved antiepileptic, 11th IBRO World Congress of Neuroscience, 9-12 sep 2023, Granada Spain, abstract published in IBRO Neuroscience Reports 15 (2023) S67–S466 (poster)
Radu BM, A new FDA-approved antiepileptic drug, cenobamate, has pro-arrhythmogenic effects, 3rd International Conference on Neuroscience, Neuroinformatics, Neurotechnology and Neuro-Psycho-Pharmacology Bucharest, 26-28 oct 2023, Romanian Academy Library, Bucharest (oral presentation)
Draghici I, Stoica R, Radu BM, Cenobamate upregulates P-glycoprotein, while downregulates tight junction proteins in accordance with blood-brain barrier permeabilization, 3rd International Conference on Neuroscience, Neuroinformatics, Neurotechnology and Neuro-Psycho-Pharmacology Bucharest, 26-28 oct 2023, Romanian Academy Library, Bucharest (poster)
Amuzescu B, Cardiological effects of cenobamate – an original research, XXXI National Conference, SRIE (Romanian Society Against Epilepsy) Conference, November 23-24, 2023, Hotel Novotel, Bucharest (oral presentation)
2024-2025
Articles published in ISI indexed journals
Mateias AL, Armasescu F, Amuzescu B, Corlan AD, Radu BM, Inhibitory effects of cenobamate on multiple human cardiac ion channels and possible arrhythmogenic consequences, Biomolecules, 2024, 14(12), 1582; doi: 10.3390/biom14121582.
Sulea T, Draga S, Mernea M, Corlan AD, Radu BM, Petrescu AJ, Amuzescu B, Differential inhibition by cenobamate of canonical human Nav1.5 ion channels and several point mutants, International Journal of Molecular Sciences, 2025, 26(1):358, doi: 10.3390/ijms26010358.
Communication to conferences
Radu BM, Stoica R, Cojocaru F, Draghici I, Rusu CM, Banciu A, Banciu DD, Amuzescu B, Drug safety assessment for cenobamate by analyzing the action on blood brain barrier and the pro-arrhythmogenic effect, 18th National Conference of Biophysics with International Participation, CNB 2024, Iasi University of Life Sciences, 5-7 September 2024, Romania (oral presentation)
Radu BM, Amuzescu B, Is cenobamate a safe drug? International Day of Microorganisms ZIM2024, 4th edition, Systemic Biology and Ecology Research Platform (PCBE), Faculty of Biology of the University of Bucharest, September 19, 2024 (oral presentation)
Stoica R, Albisoru B, Amuzescu B, Radu BM, Investigating the impact of fenfluramine on P-glycoprotein expression and cardiac ionic channels, 18th National Conference of Biophysics with International Participation, CNB 2024, Iasi University of Life Sciences, 5-7 September 2024, Romania (poster)
Radu BM, Amuzescu B, Cenobamate – drug safety assessment for a new antiepileptic drug, SNN 2024, The annual National Neuroscience Society of Romania (SNN) conference with international participation, Nervous System-Body-Environment Connections in Health and Disease, 31 October – 2 November 2023, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy oral presentation)
Radu BM, Stoica R, Cojocaru F, Draghici I, Staicu CE, Rusu CM, Amuzescu B, Analysis of the pharmacological safety of the antiepileptic drug cenobamate, Annual Research Results Communication Conference at the University of Bucharest, November 25-29, 2024, “Ioan” Amphitheater Mihăilescu”, University of Bucharest (oral presentation)
Other results
Bianca Albişoru, The action of fenfluramine on the endothelial cells of the blood-brain barrier, June 2024, Bachelor Thesis, University of Bucharest, Faculty of Biology, scientific coordinator Prof Dr Beatrice Mihaela Radu
Ioana Pascale, Functional changes of human cardiac channels for voltage-dependent Na+ induced by cenobamate treatment, June 2024, Bachelor Thesis, University of Bucharest, Faculty of Biology, scientific coordinator Prof Dr Beatrice Mihaela Radu, scientific supervisor Prof Dr Bogdan Amuzescu
Andreea Larisa Mateiaş, Analysis of the cardiac safety of the drug cenobamate through the patch-clamp technique, March – September 2024, research internship, Master of Medical and Molecular Biotechnology, University of Verona, Scientific coordinators Prof Paolo Francesco Fabene (Univr), Prof Beatrice Mihaela Radu and Prof. Bogdan Amuzescu (Unibuc)